Journal article

Associations between cognition and white matter microstructure in first-episode antipsychotic-naive patients with schizophrenia and healthy controls: A multivariate pattern analysis

Marie B Thomas, Jayachandra M Raghava, Christos Pantelis, Egill Rostrup, Mette O Nielsen, Maria H Jensen, Birte Y Glenthoj, Rene CW Mandl, Bjorn H Ebdrup, Birgitte Fagerlund

CORTEX | ELSEVIER MASSON, CORP OFF | Published : 2021

Abstract

BACKGROUND: Cognitive functions have been associated with white matter (WM) microstructure in schizophrenia, but most studies are limited by examining only select cognitive measures and single WM tracts in chronic, medicated patients. It is unclear if the cognition-WM relationship differs between antipsychotic-naïve patients with schizophrenia and healthy controls, as differential associations have not been directly examined. Here we examine if there are differential patterns of associations between cognition and WM microstructure in first-episode antipsychotic-naïve patients with schizophrenia and healthy controls, and we characterize reliable contributors to the pattern of associations acr..

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University of Melbourne Researchers

Grants

Awarded by Lundbeck Foundation


Awarded by NHMRC Senior Principal Research Fellowship


Awarded by Brain and Behavior Research Foundation Distinguished Investigator Award [US]


Awarded by Lundbeck Award


Funding Acknowledgements

This work was supported by a Ph.D. grant from the Faculty of Social Sciences, University of Copenhagen, independent grants from the Lundbeck Foundation [grant numbers R13A1349, R25-A2701, R155-2013-16337]. Prof. C. Pantelis was supported by a NHMRC Senior Principal Research Fellowship [grant number 1105825], a Brain and Behavior Research Foundation Distinguished Investigator Award [US; Grant ID: 18722] and Lundbeck Award [ID R246-2016-3237].