Journal article

Diarrhea in an infant due to Shigella flexneri 1 carrying multiple cephalosporinase-encoding genes

M John Albert, Prashant Purohit, Laurent Poirel, Glen Carter, Dieter Bulach

GUT PATHOGENS | BMC | Published : 2021


BACKGROUND: Infections caused by multidrug-resistant shigellae resistant to broad-spectrum cephalosporins are becoming more prevalent in the Middle East. We report a case of severe diarrhea due to a multiresistant Shigella flexneri 1 strain carrying four different ß-lactamase genes. CASE PRESENTATION: A one-year-old Syrian infant presented with severe acute diarrhea, vomiting and dehydration. She did not respond to empirical treatment with amoxicillin-clavulanic acid followed by cefotaxime. Later, stool culture revealed S. flexneri 1 resistant to both these drugs. The patient was successfully treated with meropenem to which S. flexneri 1 was susceptible. The isolate was resistant to eight cl..

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