Journal article

Time-Benefit Association is Magnified in Door-To-Puncture Window: Lose 1 Second, Lose 2.2 Hours of Healthy Life

Mohammed A Almekhlafi, Mayank Goyal, Diederik W Dippel, Charles B Majoie, Bruce Campbell, Keith W Muir, Andrew M Demchuk, Serge Bracard, Francis Guillemin, Tudor G Jovin, Peter J Mitchell, Philip White, Michael D Hill, Scott Brown, Jeffrey L Saver



Background: The benefits of endovascular thrombectomy (EVT) are time dependent. Prior studies may have underestimated the magnitude of the time-benefit relation because time of onset (last known well ”LKW”) is imprecisely known, and analyses including late-arriving patients have under-representation of “fast-progressors.” Methods: Patient level data were pooled by the HERMES Investigators from all 7 RCTs of stent retriever thrombectomy devices (entirely or predominantly) versus medical therapy. Analysis was confined to early-treated patients (LKW-to-puncture≤4h). Exposures: last known well-to-door (LKWTD) time; door-to-puncture (DTP) ..

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