Journal article

Humoral immune responses to AAV gene therapy in the ocular compartment

Michael Whitehead, Andrew Osborne, Patrick Yu-Wai-Man, Keith Martin

BIOLOGICAL REVIEWS | WILEY | Published : 2021

Abstract

Viral vectors can be utilised to deliver therapeutic genes to diseased cells. Adeno-associated virus (AAV) is a commonly used viral vector that is favoured for its ability to infect a wide range of tissues whilst displaying limited toxicity and immunogenicity. Most humans harbour anti-AAV neutralising antibodies (NAbs) due to subclinical infections by wild-type virus during infancy and these pre-existing NAbs can limit the efficiency of gene transfer depending on the target cell type, route of administration and choice of serotype. Vector administration can also result in de novo NAb synthesis that could limit the opportunity for repeated gene transfer to diseased sites. A number of strategi..

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