Late gadolinium enhancement identified with cardiac magnetic resonance imaging in sarcoidosis patients is associated with long-term ventricular arrhythmia and sudden cardiac death
James Nadel, Terase Lancefield, Aleksandr Voskoboinik, Andrew J Taylor
European Heart Journal - Cardiovascular Imaging | OXFORD UNIV PRESS | Published : 2015
AIMS: Cardiac involvement with sarcoidosis is a major cause of morbidity and mortality in affected individuals. Cardiac magnetic resonance (CMR) imaging promises a new and more accurate assessment of cardiac sarcoidosis by identifying typical patterns of myocardial fibrosis. We assessed the utility of CMR in the prediction of adverse outcomes. METHODS AND RESULTS: One hundred and six CMR patients with biopsy-proven extracardiac and/or presumed cardiac sarcoidosis were enrolled. Late gadolinium enhancement (LGE) on CMR typical of sarcoidosis was used to determine the presence of cardiac involvement. Clinical endpoints and medical records were assessed and those with implantable cardioverter-d..View full abstract
A.J.T. is supported by an Australian National Health and Medical Research Council (NHMRC) Project grant. The authors would also like to acknowledge Dr Michael Esler for his contribution to the statistical analysis.