Journal article

Re-evaluation of a Neonatal Mouse Model of Infection With Enterotoxigenic Escherichia coli

Carla J Carroll, Dianna M Hocking, Kristy I Azzopardi, Judyta Praszkier, Vicki Bennett-Wood, Kaylani Almeida, Danielle J Ingle, Sarah L Baines, Marija Tauschek, Roy M Robins-Browne

FRONTIERS IN MICROBIOLOGY | FRONTIERS MEDIA SA | Published : 2021

Abstract

Enterotoxigenic E. coli (ETEC) is a common cause of diarrhea in children in low- and middle-income countries, and in travelers to these countries. ETEC is also an important cause of morbidity and premature mortality in piglets, calves, goat kids and lambs. The major virulence determinants of ETEC are enterotoxins and colonization factors, which enable the pathogen to colonize the small intestine and deliver enterotoxins, such as the heat-stable enterotoxins, STp and STh, to epithelial cells. Because most ETEC strains are host-specific, there are few convenient animal models to investigate the pathogenesis of ETEC infections or to evaluate specific anti-ETEC interventions, such as drugs and v..

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Grants

Funding Acknowledgements

This work was supported by grants from the Australian National Health and Medical Research Council (NHMRC) and the University of Melbourne.