Journal article

Outcomes of Thermal Ablation of the Mucosal Defect Margin After Endoscopic Mucosal Resection: A Prospective, International, Multicenter Trial of 1000 Large Nonpedunculated Colorectal Polyps

Mayenaaz Sidhu, Neal Shahidi, Sunil Gupta, Lobke Desomer, Sergei Vosko, W Arnout van Hattem, Luke F Hourigan, Eric YT Lee, Alan Moss, Spiro Raftopoulos, Steven J Heitman, Stephen J Williams, Simon Zanati, David J Tate, Nicholas Burgess, Michael J Bourke



BACKGROUND & AIMS: Thermal ablation of the defect margin after endoscopic mucosal resection (EMR-T) for treating large (≥20 mm) nonpedunculated colorectal polyps (LNPCPs) has shown efficacy in a randomized trial, with a 4-fold reduction, in residual or recurrent adenoma (RRA) at first surveillance colonoscopy (SC1). The clinical effectiveness of this treatment, in the real world, remains unknown. METHODS: We sought to evaluate the effectiveness of EMR-T in an international multicenter prospective trial (NCT02957058). The primary endpoint was the frequency of RRA at SC1. Detailed demographic, procedural, and outcome data were recorded. Exclusion criteria were LNPCPs involving the ileo-caecal ..

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University of Melbourne Researchers


Funding Acknowledgements

The Cancer Institute of New South Wales provided funding for a research nurse and data manager to assist with the administration of the study. The Gallipoli Medical Research Foundation provided funding and support for research at Greenslopes Private Hospital. Neal Shahidi is supported by the University of British Columbia Clinician Investigator Program. There was no influence from any institution regarding study design or conduct, data collection, management, analysis, interpretation, preparation, review, or approval of the manuscript.