Prolonged atrazine exposure beginning in utero and adult uterine morphology in mice.
Meaghan J Griffiths, Amy L Winship, Jessica M Stringer, Elyse O Swindells, Alesia P Harper, Bethany J Finger, Karla J Hutt, Mark P Green
J Dev Orig Health Dis | Published : 2021
Through drinking water, humans are commonly exposed to atrazine, a herbicide that acts as an endocrine and metabolic disruptor. It interferes with steroidogenesis, including promoting oestrogen production and altering cell metabolism. However, its precise impact on uterine development remains unknown. This study aimed to determine the effect of prolonged atrazine exposure on the uterus. Pregnant mice (n = 5/group) received 5 mg/kg body weight/day atrazine or DMSO in drinking water from gestational day 9.5 until weaning. Offspring continued to be exposed until 3 or 6 months of age (n = 5-9/group), when uteri were collected for morphological and molecular analyses and steroid quantification. E..View full abstract