Differing performance of two assays for the measurement of anti-Mullerian hormone in premenopausal women: A cross-sectional study.
Robin J Bell, Marina A Skiba, Ken Sikaris, Angela Liu, Rakibul M Islam, Susan R Davis
Clin Endocrinol (Oxf) | Published : 2021
OBJECTIVE: To compare the performance of two anti-Mullerian (AMH) assays over a range of concentrations, in samples collected from young women. DESIGN: A cross-sectional method-comparison study of 168 non-healthcare-seeking women. PARTICIPANTS: Included women were aged 18-39 years, not recently pregnant, breast feeding or using systemic hormones. MEASUREMENTS: Serum AMH levels were analysed with the Beckman Coulter Access 2 assay from fresh samples and the Ansh picoAMH assay using samples stored at -80°C, in a parallel setting. Comparisons between the two assays were examined using Bland-Altman plots. RESULTS: Participants had a mean ± SD age of 32.6 ± 5.4 years and body mass index of 28.1 ±..View full abstract