Journal article

Effectors Targeting the Unfolded Protein Response during Intracellular Bacterial Infection

Manal H Alshareef, Elizabeth L Hartland, Kathleen McCaffrey

MICROORGANISMS | MDPI | Published : 2021

Abstract

The unfolded protein response (UPR) is a homeostatic response to endoplasmic reticulum (ER) stress within eukaryotic cells. The UPR initiates transcriptional and post-transcriptional programs to resolve ER stress; or, if ER stress is severe or prolonged, initiates apoptosis. ER stress is a common feature of bacterial infection although the role of the UPR in host defense is only beginning to be understood. While the UPR is important for host defense against pore-forming toxins produced by some bacteria, other bacterial effector proteins hijack the UPR through the activity of translocated effector proteins that facilitate intracellular survival and proliferation. UPR-mediated apoptosis can li..

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Grants

Awarded by Australian National Health and Medical Research Council


Awarded by Saudi Government


Funding Acknowledgements

This research was funded by the Australian National Health and Medical Research Council grant number APP1175976 (E.L.H.) and the Saudi Government grant number 4380089973 (M.H.A.).