Journal article

The association of enteric neuropathy with gut phenotypes in acute and progressive models of Parkinson's disease

Rachel M McQuade, Lewis M Singleton, Hongyi Wu, Sophie Lee, Remy Constable, Madeleine Di Natale, Mitchell T Ringuet, Joel P Berger, Jessica Kauhausen, Clare L Parish, David Finkelstein, John B Furness, Shanti Diwakarla

SCIENTIFIC REPORTS | NATURE RESEARCH | Published : 2021

Abstract

Parkinson's disease (PD) is associated with neuronal damage in the brain and gut. This work compares changes in the enteric nervous system (ENS) of commonly used mouse models of PD that exhibit central neuropathy and a gut phenotype. Enteric neuropathy was assessed in five mouse models: peripheral injection of MPTP; intracerebral injection of 6-OHDA; oral rotenone; and mice transgenic for A53T variant human α-synuclein with and without rotenone. Changes in the ENS of the colon were quantified using pan-neuronal marker, Hu, and neuronal nitric oxide synthase (nNOS) and were correlated with GI function. MPTP had no effect on the number of Hu+ neurons but was associated with an increase in Hu+ ..

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Grants

Awarded by Jack Brockhoff Early Career Research Grant


Awarded by NHMRC


Funding Acknowledgements

This work was supported by Jack Brockhoff Early Career Research Grant (ID: 4506), NHMRC Project Grant (APP1145686).