Journal article

Brain morphology is differentially impacted by peripheral cytokines in schizophrenia-spectrum disorder

Liliana Laskaris, Sam Mancuso, Cynthia Shannon Weickert, Andrew Zalesky, Gursharan Chana, Cassandra Wannan, Chad Bousman, Bernhard T Baune, Patrick McGorry, Christos Pantelis, Vanessa L Cropley

Brain, Behavior, and Immunity | Elsevier | Published : 2021

Abstract

Deficits in brain morphology are one of the most widely replicated neuropathological features in schizophrenia-spectrum disorder (SSD), although their biological underpinnings remain unclear. Despite the existence of hypotheses by which peripheral inflammation may impact brain structure, few studies have examined this relationship in SSD. This study aimed to establish the relationship between peripheral markers of inflammation and brain morphology and determine whether such relationships differed across healthy controls and individuals with first episode psychosis (FEP) and chronic schizophrenia. A panel of 13 pro- and anti-inflammatory cytokines were quantified from serum in 175 participant..

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Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by University of Melbourne Early Career Researcher grant


Awarded by Royal Melbourne Hospital


Awarded by NARSAD Distinguished Investigator Grant


Funding Acknowledgements

This work was supported by an Australian National Health and Medical Research Council (NHMRC) Project Grant (1065742) and University of Melbourne Early Career Researcher grant (601253) to Vanessa Cropley; and a Royal Melbourne Hospital Grant in Aid (GIA-030-2016) and NARSAD Distinguished Investigator Grant to Christos Pantelis (18722).