Journal article

Genomic Insights Into Last-Line Antimicrobial Resistance in Multidrug-Resistant Staphylococcus and Vancomycin-Resistant Enterococcus

Adrianna M Turner, Jean YH Lee, Claire L Gorrie, Benjamin P Howden, Glen P Carter

FRONTIERS IN MICROBIOLOGY | FRONTIERS MEDIA SA | Published : 2021

Abstract

Multidrug-resistant Staphylococcus and vancomycin-resistant Enterococcus (VRE) are important human pathogens that are resistant to most clinical antibiotics. Treatment options are limited and often require the use of 'last-line' antimicrobials such as linezolid, daptomycin, and in the case of Staphylococcus, also vancomycin. The emergence of resistance to these last-line antimicrobial agents is therefore of considerable clinical concern. This mini-review provides an overview of resistance to last-line antimicrobial agents in Staphylococcus and VRE, with a particular focus on how genomics has provided critical insights into the emergence of resistant clones, the molecular mechanisms of resist..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia Ideas grant


Awarded by NHMRC Practitioner Fellowship


Funding Acknowledgements

This work was supported by the Australian Government Research Training Program (AMT). GC was supported by a National Health and Medical Research Council (NHMRC) of Australia Ideas grant (GNT1185213). BH was supported by a NHMRC Practitioner Fellowship (GNT1105905).