TNF signaling via TNF receptors does not mediate the effects of short-term exercise on cognition, anxiety and depressive-like behaviors in middle-aged mice
Gaurav Singhal, Magdalene C Jawahar, Julie Morgan, Frances Corrigan, Emily J Jaehne, Catherine Toben, Anthony J Hannan, Shalem Yiner-Lee Leemaqz, Bernhard T Baune
BEHAVIOURAL BRAIN RESEARCH | ELSEVIER | Published : 2021
BACKGROUND: We recently reported that tumor necrosis factor (TNF) signaling via the TNFR1 and TNFR2 receptors mediates the effects of long-term exercise on locomotion, cognition and anxiety, but not depressive-like behavior. We now investigated whether the TNF signaling via its receptors also mediates the effects of short-term exercise on cognition, anxiety and depressive-like behaviors. METHODS: Thirteen-month-old C57BL/6 (WT), TNF-/-, TNFR1-/-, and TNFR2-/- mice were provided with 4 weeks of voluntary wheel running followed by behavioral testing using an established behavioral battery. Each genotype had a respective non-exercise control. RESULTS: There was no interaction between genotype a..View full abstract
Awarded by National Health and Medical Research Council Australia
The presented work is supported by the National Health and Medical Research Council Australia (APP 1043771 to BTB). AJH is an NHMRC Principal Research Fellow. The funders had no role in study design, data collection, analysis, decision to publish, or preparation of the manuscript.