Journal article

Modeling Type 1 Diabetes Using Pluripotent Stem Cell Technology

Kriti Joshi, Fergus Cameron, Swasti Tiwari, Stuart I Mannering, Andrew G Elefanty, Edouard G Stanley

FRONTIERS IN ENDOCRINOLOGY | FRONTIERS MEDIA SA | Published : 2021

Abstract

Induced pluripotent stem cell (iPSC) technology is increasingly being used to create in vitro models of monogenic human disorders. This is possible because, by and large, the phenotypic consequences of such genetic variants are often confined to a specific and known cell type, and the genetic variants themselves can be clearly identified and controlled for using a standardized genetic background. In contrast, complex conditions such as autoimmune Type 1 diabetes (T1D) have a polygenic inheritance and are subject to diverse environmental influences. Moreover, the potential cell types thought to contribute to disease progression are many and varied. Furthermore, as HLA matching is critical for..

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Grants

Awarded by National Health and Medical Research Council (Australia)


Awarded by Juvenile Diabetes research foundation


Awarded by Diabetes Australia


Awarded by Government of India: Department of Science and Technology


Awarded by Government of India: Human resource division


Awarded by Sanjay Gandhi Post Graduate Institute of Medical Sciences India


Funding Acknowledgements

The work quoted in this manuscript was supported by grants from the National Health and Medical Research Council (Australia) (GNT1068866, GNT1079004, GNT1117596, GNT1129861, GNT1138717), the Juvenile Diabetes research foundation (3-SRA-2018-603-M-B), Diabetes Australia (Y19GSTAE), the Government of India: Department of Science and Technology (DST/INT/ISR/P-23/2017), Human resource division (HRD-F.5-6/2013-TS. VII), and from Sanjay Gandhi Post Graduate Institute of Medical Sciences India (A PGI/DIR/RC/844/2018).