Infant pacifier sanitization and risk of challenge- proven food allergy: A cohort study
Victoria X Soriano, Jennifer J Koplin, Mike Forrester, Rachel L Peters, Martin O'Hely, Shyamali C Dharmage, Rosemary Wright, Sarath Ranganathan, David Burgner, Kristie Thompson, Terence Dwyer, Peter Vuillerman, Anne-Louise Ponsonby
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | MOSBY-ELSEVIER | Published : 2021
BACKGROUND: Environmental microbial exposure plays a role in immune system development and susceptibility to food allergy. OBJECTIVE: We sought to investigate whether infant pacifier use during the first postnatal year, with further consideration of sanitization, alters the risk of food allergy by age 1 year. METHODS: The birth cohort recruited pregnant mothers at under 28 weeks' gestation in southeast Australia, with 894 families followed up when infants turned 1 year. Infants were excluded if born under 32 weeks, with a serious illness, major congenital malformation, or genetic disease. Questionnaire data, collected at recruitment and infant ages 1, 6, and 12 months, included pacifier use ..View full abstract
The establishment work and infrastructure for the Barwon Infant Study was provided by the Murdoch Children's Research Institute, Deakin University, and Barwon Health. Subsequent funding was secured from the National Health and Medical Research Council of Australia (NHMRC), The Jack Brockhoff Foundation, the Scobie Trust, the Shane O'Brien Memorial Asthma Foundation, the OurWomen's Our Children's Fund Raising Committee Barwon Health, The Shepherd Foundation, the Rotary Club of Geelong, the Ilhan Food Allergy Foundation, GMHBA Limited, Vanguard Investments Australia Ltd, and the Percy Baxter Charitable Trust, Perpetual Trustees. In kind support was provided by the Cotton On Foundation and CreativeForce. The study sponsors were not involved in the collection, analysis, and interpretation of data; writing of the report; nor the decision to submit the report for publication. Research at the Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Program. V.X.S. is supported by a PhD scholarship from the NHMRC-funded Centre for Food and Allergy Research. R.L.P. and J.J.K. are supported by NHMRC-funded fellowships.