Maternal Heat Stress Alters Expression of Genes Associated with Nutrient Transport Activity and Metabolism in Female Placentae from Mid-Gestating Pigs
Weicheng Zhao, Fan Liu, Christina D Marth, Mark P Green, Hieu H Le, Brian J Leury, Alan W Bell, Frank R Dunshea, Jeremy J Cottrell
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | MDPI | Published : 2021
Placental insufficiency is a known consequence of maternal heat stress during gestation in farm animals. The molecular regulation of placentae during the stress response is little known in pigs. This study aims to identify differential gene expression in pig placentae caused by maternal heat exposure during early to mid-gestation. RNA sequencing (RNA-seq) was performed on female placental samples from pregnant pigs exposed to thermoneutral control (CON; constant 20 °C; n = 5) or cyclic heat stress (HS; cyclic 28 to 33 °C; n = 5) conditions between d40 and d60 of gestation. On d60 of gestation, placental efficiency (fetal/placental weight) was decreased (p = 0.023) by maternal HS. A total of ..View full abstract
Awarded by Australian Pork Limited (APL)
This study was partially funded by Australian Pork Limited (APL; 2017/2216). Weicheng Zhao has been awarded the Postgraduate Research Scholarship and the Melbourne Research Scholarship from APL and the University of Melbourne, respectively.