Journal article

A prospective, randomized, double-blind trial of intravenous chlorpromazine versus intravenous prochlorperazine for the treatment of acute migraine in adults presenting to the emergency department

Sarah E Hodgson, Andrew M Harding, Elyssia M Bourke, David M Taylor, Shaun L Greene

Headache The Journal of Head and Face Pain | WILEY | Published : 2021

Abstract

OBJECTIVE: To compare the efficacy of intravenous chlorpromazine versus intravenous prochlorperazine for the treatment of acute migraine in adults presenting to the emergency department (ED). BACKGROUND: Migraine is a common, incapacitating neurological condition. Although chlorpromazine and prochlorperazine are known to be safe, efficacious treatments for migraine, they have never been directly compared. DESIGN: We performed a prospective, randomized, double-blind clinical trial at a tertiary hospital in Melbourne, Australia. Adults aged 18-65 years, who presented with migraine, were eligible for recruitment. Sixty-six patients were randomized to either chlorpromazine 12.5 mg or prochlorper..

View full abstract

University of Melbourne Researchers

Grants

Funding Acknowledgements

This study was funded internally by the Emergency Department, Austin Health