Experimental infection with the hookworm, Necator americanus, is associated with stable gut microbial diversity in human volunteers with relapsing multiple sclerosis
Timothy P Jenkins, David I Pritchard, Radu Tanasescu, Gary Telford, Marina Papaiakovou, Riccardo Scotti, Alba Cortes, Cris S Constantinescu, Cinzia Cantacessi
BMC BIOLOGY | BMC | Published : 2021
BACKGROUND: Helminth-associated changes in gut microbiota composition have been hypothesised to contribute to the immune-suppressive properties of parasitic worms. Multiple sclerosis is an immune-mediated autoimmune disease of the central nervous system whose pathophysiology has been linked to imbalances in gut microbial communities. RESULTS: In the present study, we investigated, for the first time, qualitative and quantitative changes in the faecal bacterial composition of human volunteers with remitting multiple sclerosis (RMS) prior to and following experimental infection with the human hookworm, Necator americanus (N+), and following anthelmintic treatment, and compared the findings wit..View full abstract
The clinical trial from which specimens analysed in this study were derived was supported by the MS Society of the Great Britain and Northern Ireland, the Forman Hardy Charitable Trust via the University of Nottingham, and an unrestricted grant from Bayer-Schering awarded to DIP and CSC. T.P.J. is the grateful recipient of a PhD scholarship by the Biotechnology and Biological Sciences Research Council (BBSRC) of the UK. Research in the C.C. laboratory is funded by grants by the Isaac Newton Trust, the Isaac Newton Trust/Wellcome Trust/University of Cambridge joint grant scheme and by the Royal Society (UK).