Journal article

Vaccination against the brown stomach worm, Teladorsagia circumcincta, followed by parasite challenge, induces inconsistent modifications in gut microbiota composition of lambs

James Rooney, Alba Cortes, Riccardo Scotti, Daniel RG Price, Yvonne Bartley, Karen Fairlie-Clarke, Tom N McNeilly, Alasdair J Nisbet, Cinzia Cantacessi

PARASITES & VECTORS | BMC | Published : 2021

Abstract

BACKGROUND: Growing evidence points towards a role of gastrointestinal (GI) helminth parasites of ruminants in modifying the composition of the host gut flora, with likely repercussions on the pathophysiology of worm infection and disease, and on animal growth and productivity. However, a thorough understanding of the mechanisms governing helminth-microbiota interactions and of their impact on host health and welfare relies on reproducibility and replicability of findings. To this aim, in this study, we analysed quantitative and qualitative fluctuations in the faecal microbiota composition of lambs vaccinated against, and experimentally infected with, the parasitic GI nematode Teladorsagia c..

View full abstract

University of Melbourne Researchers

Grants

Awarded by Red de Investigacion Colaborativa en Enfermedades Tropicales-RICET (Ministerio de Ciencia, Innovacion y Universidades, Madrid, Spain)


Awarded by BBSRC


Awarded by European Union's Horizon 2020 Research and Innovation Programme


Funding Acknowledgements

This work was funded by the Isaac Newton Trust via a grant awarded to CC. JR is the grateful recipient of a PhD scholarship by the Biotechnology and Biological Sciences Research Council (BBSRC). AC is supported by Red de Investigacion Colaborativa en Enfermedades Tropicales-RICET (RD16/0027/0023-Ministerio de Ciencia, Innovacion y Universidades, Madrid, Spain). The authors gratefully acknowledge funding from Scottish Government Rural & Environment Science & Analytical Services (RESAS) and from the BBSRC, award number BB/L027186/1. We acknowledge funding from the European Union's Horizon 2020 Research and Innovation Programme (Grant Number: 635408).