Journal article

Involvement of the Nucleus Incertus and Relaxin-3/RXFP3 Signaling System in Explicit and Implicit Memory

Isis Gil-Miravet, Aroa Manas-Ojeda, Francisco Ros-Bernal, Esther Castillo-Gomez, Hector Albert-Gasco, Andrew L Gundlach, Francisco E Olucha-Bordonau



Telencephalic cognitive and emotional circuits/functions are strongly modulated by subcortical inputs. The main focus of past research on the nature of this modulation has been on the widespread monoamine projections to the telencephalon. However, the nucleus incertus (NI) of the pontine tegmentum provides a strong GABAergic and peptidergic innervation of the hippocampus, basal forebrain, amygdala, prefrontal cortex, and related regions; and represents a parallel source of ascending modulation of cognitive and emotional domains. NI GABAergic neurons express multiple peptides, including neuromedin-B, cholecystokinin, and relaxin-3, and receptors for stress and arousal transmitters, including ..

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University of Melbourne Researchers


Awarded by Fundacion Alicia Koplowitz, Spain

Awarded by Spanish Ministerio de Ciencia, Innovacion y Universidades

Awarded by Generalitat Valenciana

Awarded by Universitat Jaume I

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

The research by the authors reviewed in this article was funded by Fundacion Alicia Koplowitz, Spain, grant number 19I436 (FO-B, FR-B, EC-G, AM-O); the Spanish Ministerio de Ciencia, Innovacion y Universidades, grant number RTI2018-095698-B-I00 (FO-B, FR-B, EC-G, IG-M); Generalitat Valenciana, grant number GV/2019/088 (EC-G); Universitat Jaume I, grant number UJI-B2019-54 (FO-B) and UJI-A2017-17 (FR-B); and National Health and Medical Research Council of Australia, grant number 1067522 (AG).