Track C Epidemiology and Prevention Science

Abstract

Dual infection with HIV‐1 and HIV‐2, which is not uncommon in West Africa, has important implications for transmission, progression, and antiretroviral therapy. Few studies have examined HIV viral dynamics in this setting. We compared HIV‐1 and HIV‐2 viral loads from 65 dually infected, antiretroviral therapy‐naïve Senegalese subjects. Participants provided demographic information and blood, oral fluid, and cervicovaginal lavage (CVL) or semen samples for virologic and immunologic testing. Associations between HIV‐1 and HIV‐2 levels in plasma, PBMC, oral and genital samples were assessed using linear regression models with generalized estimating equations to account for subjects with multipl..