P4610Gut microbiome and atherosclerotic plaque instability: does choline consumption in red meat influence plaque stability?
Y-C Chen, V Doma, R Reimark, Y-L Ying, K Peter
European Heart Journal | Oxford University Press (OUP) | Published : 2019
Abstract Background Myocardial infarction is the major cause of deaths worldwide. Gut bacteria can process choline as abundant in red meat and subsequently converted by flavin containing monooxygenase in the liver to trimethylamin-N-oxide (TMAO) metabolite, which is strongly associated with cardiovascular events. Aim To investigate the gut microbiome and its association with atherosclerotic plaque instability. Methods Forty-eight Apolipoprotein E deficient mice were randomly divided into two groups and two ..View full abstract