Opioid agonist treatment and risk of mortality during opioid overdose public health emergency: population based retrospective cohort study.
Lindsay A Pearce, Jeong Eun Min, Micah Piske, Haoxuan Zhou, Fahmida Homayra, Amanda Slaunwhite, Mike Irvine, Gina McGowan, Bohdan Nosyk
BMJ | Published : 2020
OBJECTIVE: To compare the risk of mortality among people with opioid use disorder on and off opioid agonist treatment (OAT) in a setting with a high prevalence of illicitly manufactured fentanyl and other potent synthetic opioids in the illicit drug supply. DESIGN: Population based retrospective cohort study. SETTING: Individual level linkage of five health administrative datasets capturing drug dispensations, hospital admissions, physician billing records, ambulatory care reports, and deaths in British Columbia, Canada. PARTICIPANTS: 55 347 people with opioid use disorder who received OAT between 1 January 1996 and 30 September 2018. MAIN OUTCOME MEASURES: All cause and cause specific crude..View full abstract