Journal article
Two Nonrecombining Sympatric Forms of the Human Malaria Parasite Plasmodium ovale Occur Globally
Colin J Sutherland, Naowarat Tanomsing, Debbie Nolder, Mary Oguike, Charlie Jennison, Sasithon Pukrittayakamee, Christiane Dolecek, Tinh Hien Tran, Virgilio E do Rosario, Ana Paula Arez, Joao Pinto, Pascal Michon, Ananias A Escalante, Francois Nosten, Martina Burke, Rogan Lee, Marie Blaze, Thomas Dan Otto, John W Barnwell, Arnab Pain Show all
JOURNAL OF INFECTIOUS DISEASES | OXFORD UNIV PRESS INC | Published : 2010
DOI: 10.1086/652240
Abstract
BACKGROUND: Malaria in humans is caused by apicomplexan parasites belonging to 5 species of the genus Plasmodium. Infections with Plasmodium ovale are widely distributed but rarely investigated, and the resulting burden of disease is not known. Dimorphism in defined genes has led to P. ovale parasites being divided into classic and variant types. We hypothesized that these dimorphs represent distinct parasite species. METHODS: Multilocus sequence analysis of 6 genetic characters was carried out among 55 isolates from 12 African and 3 Asia-Pacific countries. RESULTS: Each genetic character displayed complete dimorphism and segregated perfectly between the 2 types. Both types were identified i..
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Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
Funding Acknowledgements
This work was supported by the United Kingdom Health Protection Agency and was part of the Wellcome Trust-Mahidol University-Oxford Tropical Medicine Research Programme, which is supported by the Wellcome Trust of Great Britain. P. L. C. is supported by the University College London Hospitals Comprehensive Biomedical Research Centre Infection Theme. N.T. and M. I. are supported by the Thailand Research Fund and the Commission on Higher Education. G. S. is supported by Centre National de la Recherche Scientifique and Institut National de la Sante et de la Recherche Medicale, France.