Journal article

Evaluation of Shared Genetic Susceptibility to High and Low Myopia and Hyperopia

J Willem L Tideman, Olavi Parssinen, Annechien EG Haarman, Anthony P Khawaja, Juho Wedenoja, Katie M Williams, Ginevra Biino, Xiaohu Ding, Mika Kahonen, Terho Lehtimaki, Olli T Raitakari, Ching-Yu Cheng, Jost B Jonas, Terri L Young, Joan E Bailey-Wilson, Jugnoo Rahi, Cathy Williams, Mingguang He, David A Mackey, Jeremy A Guggenheim



Importance: Uncertainty currently exists about whether the same genetic variants are associated with susceptibility to low myopia (LM) and high myopia (HM) and to myopia and hyperopia. Addressing this question is fundamental to understanding the genetics of refractive error and has clinical relevance for genotype-based prediction of children at risk for HM and for identification of new therapeutic targets. Objective: To assess whether a common set of genetic variants are associated with susceptibility to HM, LM, and hyperopia. Design, Setting, and Participants: This genetic association study assessed unrelated UK Biobank participants 40 to 69 years of age of European and Asian ancestry. Part..

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Awarded by Department for Health through National Institute for Health Research

Awarded by Special Trustees of Moorfields Eye Hospital, London, United Kingdom

Awarded by Welsh Government

Awarded by National Institutes of Health, National Eye Institute

Funding Acknowledgements

This research has been conducted using the UK Biobank Resource (applications 17351). UK Biobank was established by the Wellcome Trust, the UK Medical Research Council, the Department for Health (London, United Kingdom), Scottish Government (Edinburgh, United Kingdom), and the Northwest Regional Development Agency (Warrington, United Kingdom). It also received funding from the Welsh Assembly Government (Cardiff, United Kingdom), the British Heart Foundation, and Diabetes UK. Collection of eye and vision data was supported by grant BRC2_009 from the Department for Health through an award made by the National Institute for Health Research to the Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom. Additional support was provided by grant ST 12 09 from the Special Trustees of Moorfields Eye Hospital, London, United Kingdom. Data analysis was performed using the HAWK computing cluster, maintained by SupercomputingWales and Cardiff University Advanced Research Computing at Cardiff. This work was supported by grant 24WG201 from theWelsh Government and Fight for Sight (Dr Guggenheim), the Silmasaatio Foundation and Evald and Hilda Nissi Foundation (Dr Parssinen), grant R01EY014685 from the National Institutes of Health, National Eye Institute; a University of Wisconsin Centennial Scholars Award; and an unrestricted grant from Research to Prevent Blindness Inc to the Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison (Dr Young); and the Intramural Research Program of the National Institutes of Health (Dr Bailey-Wilson).