Journal article
Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease
KA Lidberg, AJ Annalora, M Jozic, DJ Elson, L Wang, TK Bammler, S Ramm, MB Monteiro, J Himmelfarb, CB Marcus, PL Iversen, EJ Kelly
Scientific Reports | NATURE PORTFOLIO | Published : 2021
Abstract
CYP3A5 is the primary CYP3A subfamily enzyme expressed in the human kidney and its aberrant expression may contribute to a broad spectrum of renal disorders. Pharmacogenetic studies have reported inconsistent linkages between CYP3A5 expression and hypertension, however, most investigators have considered CYP3A5*1 as active and CYP3A5*3 as an inactive allele. Observations of gender specific differences in CYP3A5*3/*3 protein expression suggest additional complexity in gene regulation that may underpin an environmentally responsive role for CYP3A5 in renal function. Reconciliation of the molecular mechanism driving conditional restoration of functional CYP3A5*3 expression from alternatively sp..
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Awarded by National Institutes of Health
Funding Acknowledgements
The authors wish to thank the Oregon State University Agricultural Research Foundation and LS Pharma for financial and material support for this project. We also wish to thank the College of Agricultural Sciences at Oregon State University, the OSU Center for Genome Research and Biocomputing, and the OSU Mass Spectrometry Center for access to their infrastructure and facilities as needed to conduct these studies. We would also like to thank the University of Washington PK Laboratory for mass spectrometry support. Research reported in this publication was supported in part by the National Institutes of Health National Center for Advancing Translational Sciences awards UG3TR002158, UH3TR002158 & UG3TR002178, National Institute of Environmental Health Sciences Interdisciplinary Center for Exposures, Diseases, Genes and Environment (UW EDGE Center; P30ES007033)),T32 (EP&T training grant-ES007032 -41A1) (KAL) and the generous unrestricted gift from the Northwest Kidney Centers to the Kidney Research Institute.