Fusion dynamics of cubosome nanocarriers with model cell membranes
Brendan P Dyett, Haitao Yu, Jamie Strachan, Calum J Drummond, Charlotte E Conn
NATURE COMMUNICATIONS | NATURE PUBLISHING GROUP | Published : 2019
Drug delivery with nanocarriers relies on the interaction of individual nanocarriers with the cell surface. For lipid-based NCs, this interaction uniquely involves a process of membrane fusion between the lipid bilayer that makes up the NC and the cell membrane. Cubosomes have emerged as promising fusogenic NCs, however their individual interactions had not yet been directly observed due to difficulties in achieving adequate resolution or disentangling multiple interactions with common characterization techniques. Moreover, many studies on these interactions have been performed under static conditions which may not mimic the actual transport of NCs. Herein we have observed fusion of lipid cu..View full abstract
Awarded by ARC DECRA Fellowship
The authors acknowledge the RMIT MicroNano Research Facility for providing access to equipment and resources. C.E.C. acknowledges support from an ARC DECRA Fellowship (DE160101281) and RMIT for a Vice Chancellor's Senior Research Fellowship.