Photoreceptor ablation following ATP induced injury triggers Muller glia driven regeneration in zebrafish
Alice Brandli, Stefanie Dudczig, Peter D Currie, Patricia R Jusuf
EXPERIMENTAL EYE RESEARCH | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2021
Retinal regeneration research offers hope to people affected by visual impairment due to disease and injury. Ongoing research has explored many avenues towards retinal regeneration, including those that utilizes implantation of devices, cells or targeted viral-mediated gene therapy. These results have so far been limited, as gene therapy only has applications for rare single-gene mutations and implantations are invasive and in the case of cell transplantation donor cells often fail to integrate with adult neurons. An alternative mode of retinal regeneration utilizes a stem cell population unique to vertebrate retina - Müller glia (MG). Endogenous MG can readily regenerate lost neurons sponta..View full abstract
We thank Dr. Ophelia Ehrlich for experimental assistance. The Australian Regenerative Medicine Institute is supported by funds from the State Government of Victoria and the Australian Federal Government. We thank FishCore facility staff (Monash University) and Walter and Eliza Hall zebrafish facility staff for housing and taking care of our animals. We thank Biological Optical Microscopy Platform (BOMP) for use of microscopes.This work was supported by a Kaye Merlin Brutton bequest (University of Melbourne) to PRJ and AB, and Advancing Women's Research Success Grant Program (Monash University) to PRJ.