Journal article

Cerebral autoregulation assessed by near-infrared spectroscopy: validation using transcranial Doppler in patients with controlled hypertension, cognitive impairment and controls

Arjen Mol, Carel GM Meskers, Marit L Sanders, Martin Mueller, Andrea B Maier, Richard JA van Wezel, Jurgen AHR Claassen, Jan Willem J Elting

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY | SPRINGER | Published : 2021

Abstract

PURPOSE: Cerebral autoregulation (CA) aims to attenuate the effects of blood pressure variation on cerebral blood flow. This study assessed the criterion validity of CA derived from near-infrared spectroscopy (NIRS) as an alternative for Transcranial Doppler (TCD). METHODS: Measurements of continuous blood pressure (BP), oxygenated hemoglobin (O2Hb) using NIRS and cerebral blood flow velocity (CBFV) using TCD (gold standard) were performed in 82 controls, 27 patients with hypertension and 94 cognitively impaired patients during supine rest (all individuals) and repeated sit to stand transitions (cognitively impaired patients). The BP-CBFV and BP-O2Hb transfer function phase shifts (TFφ) were..

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Grants

Awarded by Applied and Engineering Science domain (TTW) of the Netherlands Organization of Scientific Research (NWO): NeuroCIMT-Barocontrol


Funding Acknowledgements

This study was supported by a grant from the Applied and Engineering Science domain (TTW) of the Netherlands Organization of Scientific Research (NWO): NeuroCIMT-Barocontrol (Grant no. 14901).