Journal article

Risk of cancer in bipolar disorder and the potential role of lithium: International collaborative systematic review and meta-analyses

Gerard Anmella, Giovanna Fico, Mojtaba Lotfaliany, Diego Hidalgo-Mazzei, Oscar Soto-Angona, Anna Gimenez-Palomo, Silvia Amoretti, Andrea Murru, Joaquim Radua, Aleix Solanes, Isabella Pacchiarotti, Norma Verdolini, Stephanie Cowdery, Seetal Dodd, Lana J Williams, Mohammadreza Mohebbi, Andre F Carvalho, Lars Vedel Kessing, Eduard Vieta, Michael Berk

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2021

Abstract

We examined bipolar disorder (BD) as a risk factor for developing cancer and the role of lithium on cancer incidence. We conducted two systematic review and meta-analyses of population-based studies providing data on these associations. We screened articles indexed in MEDLINE, Scopus, Embase, and PsycINFO up to August 2020. The first random-effects meta-analysis, based on 4,910,661 individuals from nine studies estimated an increased risk of cancer of any kind [RR = 1.24 (1.05-1.46); p < 0.01], especially breast cancer [RR = 1.33 (1.15-1.55); p < 0.01] in BD. The second random-effects meta-analysis, based on 2,606,187 individuals from five studies did not show increased risk of cancer in peo..

View full abstract

University of Melbourne Researchers

Grants

Awarded by Pons Bartran 2020 grant


Awarded by Secretaria d'Universitats i Recerca del Departament d'Economia i Coneixement


Awarded by Departament de Salut de la Generalitat de Catalunya


Awarded by Spanish Ministry of Science and Innovation


Awarded by NHMRC Emerging Research Fellowship


Awarded by NHMRC


Awarded by Spanish Ministry of Science and Innovation integrated into the Plan Nacional de I + D+I


Awarded by ISCIII


Funding Acknowledgements

Dr. Anmella's research is supported by a Pons Bartran 2020 grant (PI046549) . Dr. Lotfaliany is currently funded by an Alfred Deakin Postdoctoral Research Fellowship. Dr. HidalgoMazzei's research is supported by a Juan RodesJR18/00021 to DH granted by the ISCIII. Dr. Amoretti thanks the support of the Secretaria d'Universitats i Recerca del Departament d'Economia i Coneixement (2017 SGR 1365) , the CERCA Programme, and the Departament de Salut de la Generalitat de Catalunya for the PERIS grant SLT006/17/00345. Dr. Murru thanks the support of the Spanish Ministry of Science and Innovation (PI19/00672) . Dr. Pacchiarotti thanks the support of the Spanish Ministry of Science and Innovation (PI18/01001) . Associate Professor Williams is supported by a NHMRC Emerging Research Fellowship (1174060) . Mohammadreza Mohebbi has received Grant/research support from NHMRC, Deakin University School of Medicine, Deakin Biostatistics Unit, Institute for Mental and Physical Health and Clinical Translation, and Medibank Health Research Fund. Dr. Vieta and Radua thank the support of the Spanish Ministry of Science and Innovation (PI15/00283, PI18/00805, PI19/00394, CPII19/00009) integrated into the Plan Nacional de I + D+I and cofinanced by the Instituto de Salud Carlos III (ISCIII) Subdireccion General de Evaluacion and the Fondo Europeo de Desarrollo Regional (FEDER) ; the ISCIII; the CIBER of Mental Health (CIBERSAM) ; the Secretaria d'Universitats i Recerca del Departament d'Economia i Coneixement (2017 SGR 1365) , the CERCA Programme, and the Departament de Salut de la Generalitat de Catalunya for the PERIS grant SLT006/17/00357. Dr. Berk is supported by a NHMRC Senior Principal Research Fellowship (1156072) .