Journal article
Direct Comparison of the Tau PET Tracers 18F-Flortaucipir and 18F-MK-6240 in Human Subjects
A Gogola, DS Minhas, VL Villemagne, AD Cohen, JM Mountz, TA Pascoal, CM Laymon, NS Mason, MD Ikonomovic, CA Mathis, BE Snitz, OL Lopez, WE Klunk, BJ Lopresti
Journal of Nuclear Medicine | SOC NUCLEAR MEDICINE INC | Published : 2022
Abstract
Tau PET tracers exhibit varying levels of specific signal and distinct off-target binding patterns that are more diverse than amyloid PET tracers. This study compared 2 frequently used tau PET tracers, 18F-flortaucipir and 18F-MK-6240, in the same subjects. Methods: 18F-flortaucipir and 18F-MK-6240 scans were collected within 2 mo in 15 elderly subjects varying in clinical diagnosis and cognition. Free- Surfer, version 5.3, was applied to 3-T MR images to segment Braak pathologic regions (I-VI) for PET analyses. Off-target binding was assessed in the choroid plexus, meninges, and striatum. SUV ratio (SUVR) outcomes were determined over 80-100 min (18F-flortaucipir) or 70-90 min (18F-MK-6240)..
View full abstractGrants
Awarded by National Institute on Aging
Funding Acknowledgements
GE Healthcare holds a license agreement with the University of Pittsburgh based on some of the technology described in this article. William Klunk and Chester Mathis are coinventors of 11C-PiB and, as such, have a financial interest in this license agreement. Milos Ikonomovic received research funding from GE Healthcare. This work was supported by grants from the National Institute of Aging: AG025204 and AG005133. No other potential conflict of interest relevant to this article was reported.