Journal article

Gender-related neuroanatomical differences in alcohol dependence: findings from the ENIGMA Addiction Working Group

Maria Gloria Rossetti, Praveetha Patalay, Scott Mackey, Nicholas B Allen, Albert Batalla, Marcella Bellani, Yann Chye, Janna Cousijn, Anna E Goudriaan, Robert Hester, Kent Hutchison, Chiang-Shan R Li, Rocio Martin-Santos, Reza Momenan, Rajita Sinha, Lianne Schmaal, Zsuzsika Sjoerds, Nadia Solowij, Chao Suo, Ruth J van Holst Show all

NEUROIMAGE-CLINICAL | ELSEVIER SCI LTD | Published : 2021

Abstract

Gender-related differences in the susceptibility, progression and clinical outcomes of alcohol dependence are well-known. However, the neurobiological substrates underlying such differences remain unclear. Therefore, this study aimed to investigate gender differences in the neuroanatomy (i.e. regional brain volumes) of alcohol dependence. We examined the volume of a priori regions of interest (i.e., orbitofrontal cortex, hippocampus, amygdala, nucleus accumbens, caudate, putamen, pallidum, thalamus, corpus callosum, cerebellum) and global brain measures (i.e., total grey matter (GM), total white matter (WM) and cerebrospinal fluid). Volumes were compared between 660 people with alcohol depen..

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Grants

Awarded by Netherlands Organization for Health Research and Development (ZonMW) from NWO


Awarded by ZonMW from NWO


Awarded by NIDA


Awarded by NIH National Center for Research Resources


Awarded by NIAAA


Awarded by Clive and Vera Ramaciotti Foundation for Biomedical Research National and Health and Medical Research Council


Awarded by Australian Research Council


Awarded by National Health and Medical Research Council Fellowship


Funding Acknowledgements

Drs. Sjoerds and Veltman received funding from Netherlands Organization for Health Research and Development (ZonMW) grant 31160004 from NWO. Drs. Goudriaan and van Holst received funding from ZonMW grant 91676084 from NWO. Drs. Cousijn and Goudriaan received funding for the Cannabis Prospective studyfrom ZonMW grant 31180002 from NWO. Dr. Momenan was supported by the Intramural Clinical and Biological Research Program of the National Institute on Alcohol Abuse and Alcoholism (NIAAA) . Dr. Sinha received funds from NIDA (PL301-DA024859-01) , the NIH National Center for Research Resources (UL1-RR24925-01) , and NIAAA (R01-AA013892) . Dr. Solowij received funding from the Clive and Vera Ramaciotti Foundation for Biomedical Research National and Health and Medical Research Council Project grant 459111 and was supported by Australian Research Council Future Fellowship FT110100752. Prof. Yucel was supported by National Health and Medical Research Council Fellowship 1117188 and the David Winston Turner Endowment Fund. Dr Lorenzetti was supported by The Australian Catholic University through a competitive scheme.