Diagnostic accuracy of cervical cancer screening and screening–triage strategies among women living with HIV-1 in Burkina Faso and South Africa: A cohort study

HA Kelly; A Chikandiwa; B Sawadogo; C Gilham; P Michelow; OG Lompo; T Omar; S Zan; P Magooa; M Segondy; N Nagot; N Meda; S Delany-Moretlwe; P Mayaud; E Cutler; DA Lewis; V Maseko; B Muzah; A Puren; F Djigma; J Drabo; J Simporé; A Yonli; V Costes; MN Didelot; S Doutre; N Leventoux; J Ngou; A Devine; L Gibson; R Legood; HA Weiss; C Lacey; Y Qiao; M Chirenje; S de Sanjosé; O Clavero

Journal article

Diagnostic accuracy of cervical cancer screening and screening–triage strategies among women living with HIV-1 in Burkina Faso and South Africa: A cohort study

HA Kelly, A Chikandiwa, B Sawadogo, C Gilham, P Michelow, OG Lompo, T Omar, S Zan, P Magooa, M Segondy, N Nagot, N Meda, S Delany-Moretlwe, P Mayaud, E Cutler, DA Lewis, V Maseko, B Muzah, A Puren, F Djigma Show all

Plos Medicine | Published : 2021

DOI: 10.1371/JOURNAL.PMED.1003528

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Abstract

Background Cervical cancer screening strategies using visual inspection or cytology may have suboptimal diagnostic accuracy for detection of precancer in women living with HIV (WLHIV). The optimal screen and screen–triage strategy, age to initiate, and frequency of screening for WLHIV remain unclear. This study evaluated the sensitivity, specificity, and positive predictive value of different cervical cancer strategies in WLHIV in Africa. Methods and findings WLHIV aged 25–50 years attending HIV treatment centres in Burkina Faso (BF) and South Africa (SA) from 5 December 2011 to 30 October 2012 were enrolled in a prospective evaluation study of visual inspection using acetic acid (VIA) or vi..

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