Screening for the early detection of pulmonary arterial hypertension in patients with systemic sclerosis: A systematic review and meta-analysis of long-term outcomes
Zoe Brown, Susanna Proudman, Kathleen Morrisroe, Wendy Stevens, Dylan Hansen, Mandana Nikpour
SEMINARS IN ARTHRITIS AND RHEUMATISM | W B SAUNDERS CO-ELSEVIER INC | Published : 2021
BACKGROUND: Systemic sclerosis (scleroderma, SSc) is a chronic multisystem autoimmune disease characterised by fibrosis of the skin and internal organs and vasculopathy. One of the major contributors to mortality in patients with SSc is pulmonary arterial hypertension (PAH). International recommendations advise annual screening for the early detection of PAH in asymptomatic patients with SSc. OBJECTIVES: To evaluate by systematic review current measures employed for screening for PAH. To summarise by meta-analysis the current evidence for long-term outcomes of screening for PAH in SSc. METHODS: Manuscripts published until 12th March 2019 were identified through searching Medline, Embase and ..View full abstract
Awarded by NHMRC
A/Prof Nikpour has received research funding support from Actelion, Scleroderma Australia, Scleroderma Victoria, Arthritis Australia, Australian Rheumatology Association, St. Vincent's Hospital Melbourne Research Endowment Fund (REF), GSK, Pfizer, BMS, Roche and Bayer. MN holds an NHMRC Career Development Fellowship AP1126370.Dr Brown has received research funding support from the Australian Commonwealth Government through the University of Melbourne Research Training Program Scholarship.