Journal article

Prednisolone Alters Endometrial Decidual Cells and Affects Decidual-Trophoblast Interactions

Eliza Grbac, Teresa So, Swati Varshney, Nicholas Williamson, Evdokia Dimitriadis, Ellen Menkhorst

Frontiers in Cell and Developmental Biology | FRONTIERS MEDIA SA | Published : 2021

Abstract

Poor pregnancy outcomes such as recurrent pregnancy loss (RPL) and preeclampsia are associated with impaired decidualization and abnormal trophoblast invasion. Emerging evidence suggests that use of corticosteroids, including prednisolone affects fertility by altering uterine function and may be associated with preeclampsia incidence. In this study, using primary and gestational-age appropriate tissue, we aimed to define the effect of prednisolone on human endometrial stromal fibroblast (hESF) decidualization and determine whether hESF decidualization in the presence of prednisolone would alter hESF regulation of trophoblast function. We found that prednisolone treatment reduced hESF cytokin..

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Grants

Awarded by NHMRC (Australia)


Awarded by Rebecca L. Cooper Medical Research Foundation


Funding Acknowledgements

This work was supported by the NHMRC (Australia) Project/Program Grant (GNT1098332) and Fellowships (#611827 to EM and #550905 to ED), Rebecca L. Cooper Medical Research Foundation project grant PG2018130 to EM, the University of Melbourne Department of Obstetrics and Gynecology Mid-career Fellowship to EM, and the Victorian Government's Operational Infrastructure Support. The funders had no involvement in the conduct of research, preparation of the manuscript or the decision to publish.