Journal article

Pharmacological Management of Paroxysmal Sympathetic Hyperactivity: A Scoping Review

Justin Siew Yoong Tu, Jake Reeve, Adam M Deane, Mark P Plummer

JOURNAL OF NEUROTRAUMA | MARY ANN LIEBERT, INC | Published : 2021

Abstract

Paroxysmal sympathetic hyperactivity (PSH) occurs in ∼10% of patients following acute severe brain injury. While PSH is associated with worse outcomes, there are no clinical practice guidelines to inform treatment. We aimed to systematically review the literature on the pharmacological management of PSH. MEDLINE, Embase, and Cochrane library databases were searched from inception to August 2020. Eligible studies met the following criteria: 1) randomized controlled trials, non-randomized controlled trials (case control or controlled cohort), observational studies, case series, and case reports; 2) study population of adult and pediatric patients; 3) exposure to an acute neurological insult co..

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