Novel hepaci- and pegi-like viruses in native Australian wildlife and non-human primates.
Ashleigh F Porter, John H-O Pettersson, Wei-Shan Chang, Erin Harvey, Karrie Rose, Mang Shi, John-Sebastian Eden, Jan Buchmann, Craig Moritz, Edward C Holmes
Virus Evolution | Oxford University Press | Published : 2020
The Flaviviridae family of positive-sense RNA viruses contains important pathogens of humans and other animals, including Zika virus, dengue virus, and hepatitis C virus. The Flaviviridae are currently divided into four genera-Hepacivirus, Pegivirus, Pestivirus, and Flavivirus-each with a diverse host range. Members of the genus Hepacivirus are associated with an array of animal species, including humans, non-human primates, other mammalian species, as well as birds and fish, while the closely related pegiviruses have been identified in a variety of mammalian taxa, also including humans. Using a combination of total RNA and whole-genome sequencing we identified four novel hepaci-like viruses..View full abstract