The origins and genomic diversity of American Civil War Era smallpox vaccine strains.
Ana T Duggan, Jennifer Klunk, Ashleigh F Porter, Anna N Dhody, Robert Hicks, Geoffrey L Smith, Margaret Humphreys, Andrea M McCollum, Whitni B Davidson, Kimberly Wilkins, Yu Li, Amanda Burke, Hanna Polasky, Lowell Flanders, Debi Poinar, Amogelang R Raphenya, Tammy TY Lau, Brian Alcock, Andrew G McArthur, G Brian Golding Show all
Genome Biology | BioMed Central | Published : 2020
Vaccination has transformed public health, most notably including the eradication of smallpox. Despite its profound historical importance, little is known of the origins and diversity of the viruses used in smallpox vaccination. Prior to the twentieth century, the method, source and origin of smallpox vaccinations remained unstandardised and opaque. We reconstruct and analyse viral vaccine genomes associated with smallpox vaccination from historical artefacts. Significantly, we recover viral molecules through non-destructive sampling of historical materials lacking signs of biological residues. We use the authenticated ancient genomes to reveal the evolutionary relationships of smallpox vacc..View full abstract