Anti-cancer effects of polyphenol-rich sugarcane extract
Monica D Prakash, Lily Stojanovska, Jack Feehan, Kulmira Nurgali, Elizabeth L Donald, Magdalena Plebanski, Matthew Flavel, Barry Kitchen, Vasso Apostolopoulos
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2021
Plant polyphenols have an array of health benefits primarily thought to be related to their high content of anti-oxidants. These are commonly undervalued and knowledge of their biological properties have grown exponentially in the last decade. Polyphenol-rich sugarcane extract (PRSE), a natural extract from sugar cane, is marketed as high in anti-oxidants and polyphenols, but its anti-cancer activity has not been reported previously. We show that, PRSE exerts anti-cancer properties on a range of cancer cells including human (LIM2045) and mouse (MC38, CT26) colon cancer cells lines; human lung cancer (A549), human ovarian cancer (SKOV-3), pro-monocytic human leukemia (U937) and to mouse melan..View full abstract
The study was supported by The Product Makers (TPM) (Australia) Pty Ltd (http://www.tpm.com.au/) and the Innovation Connections Grant, Department of Industry, Innovation and Science, VIC Australia (https://www.industry.gov.au/).The funder (TPM) provided support in the form of salaries for authors M.F and B.K but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the 'author contributions' section. VA was the recipient of all funding for this study.