Journal article
Evaluation of the novel 18F‐labeled PET tracer SMBT‐1 for imaging astrogliosis in healthy elderly controls and A /T /(N ) Alzheimer's disease patients
Victor LL Villemagne, Ryuichi Harada, Vincent Dore, Shozo Furumoto, Rachel S Mulligan, Yukitsuka Kudo, Samantha C Burnham, Natasha Krishnadas, Kun Huang, Kazuhiko Yanai, Christopher C Rowe, Nobuyuki Okamura
Alzheimer's & Dementia | Wiley | Published : 2020
DOI: 10.1002/alz.039858
Abstract
AbstractBackgroundNeuroinflammatory changes, characterized by reactive astrocytes and activated microglia, contribute greatly to neurodegeneration throughout the course of Alzheimer’s diseases (AD). Reactive astrocytes overexpress monoamine oxidase‐B (MAO‐B) in the outer mitochondrial membrane. For imaging astrogliosis in the human brain, we developed the novel MAO‐B PET tracer named 18F‐SMBT‐1. We aimed to investigate the binding properties of 18F‐SMBT‐1 in healthy elderly controls and AD patients.MethodsAfter in silico preclinical evaluation were performed for the assessment of binding affinity and selectivity of 18F‐SMBT‐1, 9 participants, 5 healthy elderly controls (3F/2M, 78.5±6.0 yrs, ..
View full abstract