0297 An Association Between Amyloid Burden and Cognition in Severe Obstructive Sleep Apnea

Abstract

Obstructive Sleep Apnea (OSA) is more prevalent in dementia patients than in the general population, and OSA increases the risk of developing Alzheimer’s Disease (AD). AD markers, amyloid and tau, measured in cerebrospinal fluid and serum, have previously been associated with OSA measures in cognitively normal older adults, however, these are relatively indirect measures of amyloid burden. This pilot study evaluated the degree of Pittsburgh Compound B (PiB) retention as a measure of amyloid burden in OSA using positron emission tomography (PET) and determined its association with clinical and neurocognitive measures. N=16 treatment-naïve individuals with OSA (mean±SD age=54.1 ± 8.7 years; AH..