Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes

T Li; D van Rooij; N Roth Mota; JK Buitelaar; M Hoogman; A Arias Vasquez; B Franke; S Ambrosino; T Banaschewski; CE Bandeira; CHD Bau; S Baumeister; R Baur-Streubel; MA Bellgrove; J Biederman; J Bralten; IE Bramati; D Brandeis; S Berm; GF Busatto; A Calvo; FX Castellanos; M Cercignani; KC Chantiluke; A Christakou; D Coghill; A Conzelmann; AI Cubillo; RB Cupertino; P de Zeeuw; S Durston; EA Earl; JN Epstein; T Ethofer; AJ Fallgatter; DA Fair; SV Faraone; T Frodl; MC Gabel; T Gogberashvili; EH Grevet; J Haavik; NA Harrison; CA Hartman; DJ Heslenfeld; PJ Hoekstra; MF Høvik; N Jahanshad; B Kardatzki; G Karkashadze; C Kelly; G Kohls; K Konrad; J Kuntsi; L Lazaro; S Lera-Miguel; KP Lesch; MR Louza; AJ Lundervold; CB Malpas; P Mattos; H McCarthy; R Nicolau; JT Nigg; RL O'Gorman Tuura; J Oosterlaan; B Oranje; Y Paloyelis; P Pauli; FA Picon; KJ Plessen; JA Ramos-Quiroga; A Reif; L Reneman; PGP Rosa; K Rubia; A Schrantee; LJS Schweren; J Seitz; P Shaw; TJ Silk; N Skokauskas; J Carlos Soliva Vila; A Soloveva; MC Stevens; G Sudre; L Tamm; PM Thompson; F Tovar-Moll; TGM van Erp; A Vance; O Vilarroya; Y Vives-Gilabert; GG von Polier; S Walitza; YN Yoncheva; MV Zanetti; GC Ziegler; A Anikin; P Asherson

Journal article

Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes

T Li, D van Rooij, N Roth Mota, JK Buitelaar, M Hoogman, A Arias Vasquez, B Franke, S Ambrosino, T Banaschewski, CE Bandeira, CHD Bau, S Baumeister, R Baur-Streubel, MA Bellgrove, J Biederman, J Bralten, IE Bramati, D Brandeis, S Berm, GF Busatto Show all

Journal of Child Psychology and Psychiatry and Allied Disciplines | WILEY | Published : 2021

DOI: 10.1111/jcpp.13384

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Abstract

Background: Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder. Neuroanatomic heterogeneity limits our understanding of ADHD’s etiology. This study aimed to parse heterogeneity of ADHD and to determine whether patient subgroups could be discerned based on subcortical brain volumes. Methods: Using the large ENIGMA-ADHD Working Group dataset, four subsamples of 993 boys with and without ADHD and to subsamples of 653 adult men, 400 girls, and 447 women were included in analyses. We applied exploratory factor analysis (EFA) to seven subcortical volumes in order to constrain the complexity of the input variables and ensure more stable clustering results. Fa..

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University of Melbourne Researchers

Dave Coghill Author

Charles Malpas Author

Alasdair Vance Author

Grants

Awarded by Horizon 2020 Framework Programme

Funding Acknowledgements

T.L. is supported by China Scholarship Council (CSC) under the Grant CSC no 201507720006. ENIGMA received funding from the National Institutes of Health (NIH) Consortium grant U54 EB020403, supported by a cross-NIH alliance that funds Big Data to Knowledge Centers of Excellence (BD2K). Support was also received from the European Community's Horizon 2020 Programme (H2020/2014-2020) under grant agreements no. 667302 (CoCA) and no. 728018 (Eat2-beNICE). M.H. and B.F. were supported by personal grants from the Netherlands Organization for Scientific Research (NWO) Innovation Program (Veni grant 91619115 to MH; Vici grant 016-130-669 to BF). Lastly, the authors also gratefully acknowledge support from the European College for Neuropsychopharmacology (ECNP) for the ECNP Network ADHD across the Lifespan.J.K.B. has been in the past 3 years a consultant to/member of advisory board of/and/or speaker for Shire, Roche, Medice, and Servier. He is not an employee of any of these companies, and not a stock shareholder of any of these companies. He has no other financial or material support, including expert testimony, patents, royalties. In the past year, S.V.F., a contributing member of the ENIGMA-ADHD Working Group, received income, potential income, travel expenses continuing education support and/or research support from Tris, Otsuka, Arbor, Ironshore, Shire, Akili Interactive Labs, Enzymotec, Sunovion, Supernus, and Genomind. With his institution, he has US patent US20130217707 A1 for the use of sodium-hydrogen exchange inhibitors in the treatment of ADHD. He also receives royalties from books published by Guilford Press: Straight Talk about Your Child's Mental Health, Oxford University Press: Schizophrenia: The Facts, and Elsevier: ADHD: Non-Pharmacologic Interventions. He is Program Director of www.adhdinad ults.com. B.F. has received educational speaking fees from Medice. The remaining authors have declared that they have no competing or potential conflicts of interest.