Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes.
Ting Li, Daan van Rooij, Nina Roth Mota, Jan K Buitelaar, undefined ENIGMA ADHD Working Group, Martine Hoogman, Alejandro Arias Vasquez, Barbara Franke
Journal of Child Psychology and Psychiatry | Published : 2021
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder. Neuroanatomic heterogeneity limits our understanding of ADHD's etiology. This study aimed to parse heterogeneity of ADHD and to determine whether patient subgroups could be discerned based on subcortical brain volumes. METHODS: Using the large ENIGMA-ADHD Working Group dataset, four subsamples of 993 boys with and without ADHD and to subsamples of 653 adult men, 400 girls, and 447 women were included in analyses. We applied exploratory factor analysis (EFA) to seven subcortical volumes in order to constrain the complexity of the input variables and ensure more stable clustering results. Fa..View full abstract
Awarded by the European Community's Horizon 2020 Programme (H2020/2014 - 2020)
Awarded by China Scholarship Council (CSC)
Awarded by NIBIB NIH HHS
Awarded by Netherlands Organization for Scientific Research (NWO) Innovation Program