Conference Proceedings

T Cell Landscape of Immune Aplastic Anemia Reveals a Convergent Antigen-Specific Signature

Jani Huuhtanen, Sofie Lundgren, Mikko A Keranen, Xingmin Feng, Cassandra M Kerr, Emmi Jokinen, Markus Heinonen, Paula Savola, Tiina Kelkka, Freja Ebeling, Georgina L Ryland, Lucy Fox, Piers Blombery, Eva Hellstrom Lindberg, Neal S Young, Jaroslaw P Maciejewski, Harri Lahdesmaki, Satu Mustjoki

Blood | AMER SOC HEMATOLOGY | Published : 2019

Abstract

Immune aplastic anemia (AA) is a life-threatening bone marrow failure syndrome in which the hematopoietic stem cells are destroyed, leading to pancytopenia. Although the exact biological process leading to AA remains largely unknown, bone marrow destruction is thought to be mediated by an autologous T cell response. We hypothesized that the autoimmune process in AA would create a T cell fingerprint unique to aplastic anemia. To decipher this signature, we collected an international, multi-centre cohort of 245 AA-samples from bone marrow and peripheral blood profiled with T-cell receptor beta (TCRβ) -sequencing. CD8+ T cell- and MNC-sorted samples from 153 clinically annotated ..

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