Treg-mediated acquired resistance to immune checkpoint inhibitors
Reem Saleh, Eyad Elkord
Cancer Letters | ELSEVIER IRELAND LTD | Published : 2019
T Regulatory cells (Tregs) act as a double-edged sword by regulating immune homeostasis (protective role) and inhibiting immune responses in different disease settings (pathological role). They contribute to cancer development and progression by suppressing T effector cell (Teff) functions. Decreased ratios of intratumoral CD8+ T cells to Tregs have been associated with poor prognosis in most cancer types. Targeting immune checkpoints (ICs), such as cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1), by immune checkpoint inhibitors (ICIs) in cancer patients has been beneficial in inducing anti-tumor immune responses and improving clinical outcomes. Howeve..View full abstract
Awarded by Qatar Biomedical Research Institute, Qatar Foundation
This work was supported by a start-up grant [VR04] for Dr Eyad Elkord from Qatar Biomedical Research Institute, Qatar Foundation.