Journal article

Differential gene expression of tumor-infiltrating CD33( )myeloid cells in advanced- versus early-stage colorectal cancer

Salman M Toor, Rowaida Z Taha, Varun Sasidharan Nair, Reem Saleh, Khaled Murshed, Mohamed Abu Nada, Eyad Elkord

CANCER IMMUNOLOGY IMMUNOTHERAPY | SPRINGER | Published : 2020

Abstract

Colorectal cancer (CRC) has high mortality rates, especially in patients with advanced disease stages, who often do not respond to therapy. The cellular components of the tumor microenvironment are essentially responsible for dictating disease progression and response to therapy. Expansion of different myeloid cell subsets in CRC tumors has been reported previously. However, tumor-infiltrating myeloid cells have both pro- and anti-tumor roles in disease progression. In this study, we performed transcriptomic profiling of cells of myeloid lineage (CD33+) from bulk CRC tumors at varying disease stages. We identified differentially expressed genes and pathways between CRC patients with advanced..

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Grants

Awarded by Qatar Biomedical research Institute, Qatar Foundation


Funding Acknowledgements

Open Access funding was provided by the Qatar National Library. This work was supported by a start-up grant [VR04] for Prof. Eyad Elkord from Qatar Biomedical research Institute, Qatar Foundation.