Journal article

Transcriptome of CD8( ) tumor-infiltrating T cells: a link between diabetes and colorectal cancer

Reem Saleh, Varun Sasidharan Nair, Khaled Murshed, Mohamed Abu Nada, Eyad Elkord, Ranad Shaheen

CANCER IMMUNOLOGY IMMUNOTHERAPY | SPRINGER | Published : 2021

Abstract

There is an increased risk of colorectal cancer (CRC) development in patients with non-insulin-dependent type 2 diabetes. CD8+ T cells have been implicated in diabetes and are crucial for anti-tumor immunity. However, transcriptomic profiling for CD8+ T cells from CRC diabetic patients has not been explored. We performed RNA sequencing and compared transcriptomic profiles of CD8+ tumor-infiltrating T lymphocytes (CD8+ TILs) in CRC diabetic patients with CRC nondiabetic patients. We found that genes associated with ribogenesis, epigenetic regulations, oxidative phosphorylation and cell cycle arrest were upregulated in CD8+ TILs from diabetic patients, while genes associated with PI3K signalin..

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