Transcriptome of CD8( ) tumor-infiltrating T cells: a link between diabetes and colorectal cancer
Reem Saleh, Varun Sasidharan Nair, Khaled Murshed, Mohamed Abu Nada, Eyad Elkord, Ranad Shaheen
CANCER IMMUNOLOGY IMMUNOTHERAPY | SPRINGER | Published : 2021
There is an increased risk of colorectal cancer (CRC) development in patients with non-insulin-dependent type 2 diabetes. CD8+ T cells have been implicated in diabetes and are crucial for anti-tumor immunity. However, transcriptomic profiling for CD8+ T cells from CRC diabetic patients has not been explored. We performed RNA sequencing and compared transcriptomic profiles of CD8+ tumor-infiltrating T lymphocytes (CD8+ TILs) in CRC diabetic patients with CRC nondiabetic patients. We found that genes associated with ribogenesis, epigenetic regulations, oxidative phosphorylation and cell cycle arrest were upregulated in CD8+ TILs from diabetic patients, while genes associated with PI3K signalin..View full abstract
Awarded by Qatar Biomedical research Institute, Qatar Foundation
We would like to thank the patients for donating their samples. This work was supported by a start-up Grant [VR04] for Professor Eyad Elkord from Qatar Biomedical research Institute, Qatar Foundation.