Role of Epigenetic Modifications in Inhibitory Immune Checkpoints in Cancer Development and Progression
Reem Saleh, Salman M Toor, Varun Sasidharan Nair, Eyad Elkord
Frontiers in Immunology | FRONTIERS MEDIA SA | Published : 2020
A balance between co-inhibitory and co-stimulatory signals in the tumor microenvironment (TME) is critical to suppress tumor development and progression, primarily via maintaining effective immunosurveillance. Aberrant expression of immune checkpoints (ICs), including programmed cell death protein 1 (PD-1), cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), T cell immunoglobulin and mucin-domain containing-3 (TIM-3), lymphocyte-activation gene 3 (LAG-3) and T cell immunoreceptor with Ig and ITIM domains (TIGIT), can create an immune-subversive environment, which helps tumor cells to evade immune destruction. Recent studies showed that epigenetic modifications play critical roles in regula..View full abstract
Awarded by Qatar Biomedical Research Institute, Qatar Foundation
This work was supported by a start-up grant [VR04] for Prof. EE from Qatar Biomedical Research Institute, Qatar Foundation.