Expression of immune checkpoints and T cell exhaustion markers in early and advanced stages of colorectal cancer
Reem Saleh, Rowaida Z Taha, Salman M Toor, Varun Sasidharan Nair, Khaled Murshed, Mahwish Khawar, Mahmood Al-Dhaheri, Mahir Abdulla Petkar, Mohamed Abu Nada, Eyad Elkord
Cancer Immunology, Immunotherapy | SPRINGER | Published : 2020
Despite recent advances in colorectal cancer (CRC) treatment, a large proportion of patients show limited responses to therapies, especially in advanced stages. There is an urgent need to identify prognostic biomarkers and/or therapeutic targets in advanced stages, aiming to improve the efficacy of current treatments. We aimed to determine prognostic biomarkers in tumor tissue and circulation of CRC patients, with a special focus on T cell exhaustion markers. We found that mRNA levels of PD-1, TIM-3, CTLA-4, TIGIT, CD160, CD244, KLRG1, TOX2, TOX3, Ki-67, and PRDM1 were elevated in CRC tumor tissues. We also investigated differences in gene expression between early and advanced disease stages..View full abstract
Awarded by Qatar Biomedical Research Institute, Qatar Foundation
This work was supported by a start-up Grant [VR04] for Professor Eyad Elkord from Qatar Biomedical Research Institute, Qatar Foundation.