Journal article

K29/K48-branched ubiquitin chains TRIP the alarm fueling neo-substrate degradation via the CRL2(VHL)

Charlene M Magtoto, Rebecca Feltham

MOLECULAR CELL | CELL PRESS | Published : 2021

Abstract

In this issue of Molecular Cell, Kaiho-Soma et al. (2021) demonstrate that the HECT-type E3 ubiquitin ligase TRIP12 cooperates with CRL complexes to promote PROTAC-induced degradation of neo-substrates by generating K29/K48-branched ubiquitin chains.

University of Melbourne Researchers