Journal article
K29/K48-branched ubiquitin chains TRIP the alarm fueling neo-substrate degradation via the CRL2(VHL)
Charlene M Magtoto, Rebecca Feltham
MOLECULAR CELL | CELL PRESS | Published : 2021
Abstract
In this issue of Molecular Cell, Kaiho-Soma et al. (2021) demonstrate that the HECT-type E3 ubiquitin ligase TRIP12 cooperates with CRL complexes to promote PROTAC-induced degradation of neo-substrates by generating K29/K48-branched ubiquitin chains.
Grants
Funding Acknowledgements
The authors are funded by The Galbraith Family Charitable Trust.